Welcome The term "Exosome therapy" implies the use of exosomes in order to threatment of human diseases. Exosomes are a set of small (30 - 100 nm) vesicles secreted by vast types of both prokaryotic and eukaryotic cells. Although these small bodies structurally and functunally are similar another cellular vesicles, play an importanr role in transfer some biomaterials between cells and but not between organelles . Despite more than 25 years have passed since exosomes discovery, these was forgotten for many years. Fortunately, today biomedicine scientists tend to have a closer look at exosomes structure and functions. Becouse publication of a new study voincides with revealing a new dimension of exosome phenomenon. For me ( Babak Nami) as an biologist it is very pleasure knowing that cells talking together with using exosomes. Exosomes contain very versatile protein, mRNA and miRNA as key members of cell signaling process. Dr. Suresh Mathivanan and Prof. Richard Simpson from La Trobe University launched ExoCarta database serves exosomes biomaterial composions details as free for public. It is proved that malignancy associated dendritic cells secrete the exosomes that share some expected proteins and RNAs. In some cancers exosomes can make a anti-tumour immune response and anti-metastatisis effect. The term exosomal immunotherapy reffers this application of exosomes (read more). Interestingly urinary derived exosomes inclusive bimaterials that are meaningful depended some disorders in urinary system. Nowadays, scientist intend to useing urinary derived exosomal RNA as biomarkers for diagnosis of Prostate cancer and kidney failure ( read more) . Moreover many biomarkers been recognized from leukimia and ovarian cancers derived exosomes. Stem cells derived exosomes in times of embryonic development can share the signals as a set of commands to cell differentiation (read more). This can be give us a idea that explain why a organ can be regenerate themselve but another can not. Moreover we can understand the many pathways of cell signaling and obtain the golden tools for cell and tissue engineering . Bluntly, today's molucular medicine methods like "gene" therapy is faced with some problems. I put the word gene inside quotation deliberately, it means that we dont know exactly what gene should we use to treatment of diseases. In other hand, we don not know our transferred gene product what will interact with products of genes of host cell. Also replacment of gene randomly in host genome with using a viral vector is perpetual problem that has the potential to destroy patient genes and give rise to an de novo mutation. Because the exosomes are part of the self-cell, is counted among desirable vectors for DNA and RNA delivery (read more). I want to thank the all scientists who study on exosomes and anyone that pays attenton to exosome based studies. This website aims to introduction exosomes and offerring some basic information for students and encourage fresh student to more studies. I am eager to investigate exosomes and exosome based therapy approach. I am sincerely requesting collaboration and assistance in this area. My contact information is available in this website. Thank you for visiting. Babak Nami (Author)
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